The paper considers the regulation of the structural characteristics of the surface of the new medical material ─ nanotitanium using the method of molecular layering due to the application of nanostructured titaniumorganic coating brush type with a different degree of hydrophobicity. Regulation of the degree of hydrophilicity or hydrophobicity of the surface of nanotitanium with titaniumorganic nanostructures was realized by varying the conditions of synthesis of end functional groups and their chemical composition. The paper shows the possibility of controlling the surface nanotitanium by chemical structure, and found the conditions of synthesis, allowing aims to change contact angle in the range 42°- 90°.