The study considers the fatigue strength of additively manufactured specimens made of metamaterials based on Ti-6Al-4V titanium alloy. The study presents results of full-scale tests for two types of meta-biomaterials: lattice and surface. Dynamic tests were performed in a symmetrical tension-compression cycle at room temperature. The goal of the tests was to construct an S-N curve, which was used to determine the fatigue limit of the metamaterial. We found that the results of numerical simulation differ significantly from the full-scale tests, showing a trend toward overestimated fatigue life. The surface roughness parameter of the specimen was introduced, allowing to achieve better agreement between the results of full-scale tests and numerical simulations.