In this work, we have implemented the approach to improve the biocompatibility of bone implants based on creating relationships between the implant and the living tissue due to surface modification. Bioactive surface for titanium media was created through the creation of a mesoporous layer of TiO2 films with well-developed micron-sized structure. For the directional regulation of biomedical properties of the surface of nanometals used Sol-gel method. This method allowed us to obtain a mesoporous film of titanium oxide on the metal surface in the nanometer diapazone, which greatly improves the adhesion of osteoblasts (bone cells).