The current paper presents the results of a complex investigation of effect of Selective Laser Melting process parameters on microstructure and properties of Inconel 718 bulk specimens. The possibility of obtaining bulk specimens with tailored microstructure was studied. The specimens with tailored microstructure were obtained and studied. It was shown that after heat treatment and hot isostatic pressing the differences in microstructure and mechanical properties of fine-grained and coarse-grained areas still remain in place. Finally,the feasibility of applying the developed approach was shown by manufacturing a gas-turbine engine blade with tailored microstructure in specific areas.