The von Mises and Hill yield criteria are commonly used when the stress-strain state of parts under complex loading conditions is calculated. However, those yield criteria are not suitable in some materials and do not reliably describe the inelastic behavior of the material under complex stress conditions. The development of a simple and accurate criterion of plastic flow is relevant. This paper presents the results of the yield criterion development for a single crystal nickel-based superalloy (ZhS32) based on the systematization of experimental data. Various types of stress state were realized during the experiment: tension, compression, torsion, as well as combinations of tension-torsion, compression-torsion.