A theoretical study on the structural strength of an endoprosthesis stem made from meta-biomaterial is presented. We considered six types of metamaterials based on a biocompatible titanium alloy comprised by unit cells of lattice and surface structures. The standard for testing femoral components of endoprostheses was used to develop virtual test benches for simulation of the loading process, followed by stress–strain analysis of meta-biomaterial implants. Our general findings confirm the load-bearing capacity of the structures, additionally pointing to potential issues that may arise if the manufacturing technology of metamaterial endoprostheses is insufficiently rigorous.